最新青霉素类药物的结构改造.教学讲义PPT课件.ppt

'青霉素类药物的结构改造. 1.青霉素结构特征：由β-内酰胺环、氢化噻唑环及酰基侧链构成β-内酰胺环四氢噻唑环酰胺侧链一、青霉素类药物概述6-氨基青霉烷酸 2.天然青霉素存在的不足：不耐酸，只能注射给药易产生耐药性抗菌谱窄，仅对革兰阳性菌有效有严重的过敏反应 书信 感谢信ALetterofThanksIwouldliketothankyoufromthebottomofmyheartfor…I’mwritingtoexpressmysinceregratitudefor…I’mgratefultoyoufor…Itrulyappreciateyour…Wordsfailtoconveymygratitudetoyoufor… 道歉信ALetterofApologyIwouldliketoexpressmyapologyfor…Pleaseacceptmysincerestanddeepestapologyfor…I’mterriblysorrytotellyouthat…Willyoudogoodenoughtoexcusemefor…I’mwritingtoapologizetoyoufor…WouldyoumindifIchangetheappointmenttime?Tomakeupmythoughtlessbehavior,I…（我想。。。以弥补）IwishIcouldbegivenachancetomakeupformyinconsideration. 投诉信ALetterofComplaintMuchtomyregret,Iamwritingtomakeacomplaintabout/against…Iamcompletelydisappointed/upsettofind…Iamwritingtoinformyouofmyunhappyexperience.Iwouldliketodrawyourattentionto…Iwouldbeveryobligedifyoucouldlookintothismatterassoonaspossible.（若你能尽快调查此事，我讲不胜感激）Toimprovethesituation/solvetheaboveproblem,itisadvisableforyoutotakethefollowingmeasures.Iwouldliketoseeapromptsettlementoftheissue.Wewillappreciateyourwillingnesstomakeupfortheloss.（我们真的希望你们能对损失做出补偿） 建议信ALetterofSuggestionIamwritingtoexpressmyviewsconcerning…Youhaveaskedmeformyadviceabout…,andIwilltrytomakesomeconstructivesuggestions.Iwouldliketosuggestthat…Iamwritingtoputupsomesuggestionsconcerning…It’smygreathonortorecommend…Thankyouforyourattention. 申请信ALetterofApplicationIamwritingtoyouthislettertoshowmykeeninterestinthepostof…,whichyouadvertisedinyesterday’sChinaDaily.Inreplytoyouradvertisementin…,Ibegtoapplyforthepostof…inyourcompany.Iwouldliketoapplyforthepositionof…Iwouldliketoapplyforthescholarshipthatyourschoolmaybeoffering.Iamverygladtoavailmyselfofthechancetorecommendmyselftoyou.Mynameis…I’mstudyingin…,majoringin… 拒绝信ALetterofRefusalManythanksforyourletterdated10thOctober,invitingmeto…ButIamsorrytotellyouthatIshallnot…because…IamterriblysorrytosaythatIamunableto…IammuchtouchedbyyourkindinvitationbutIdonotseeanychanceofmybeingabletobethere. 询问信ALetterofInquiryI’mwritingtoseeifitispossibleforyoutoprovidemewithinformationconcerning…I’mwritingtoyouinthehopethatImayobtainsomematerialsabout…Iwouldbegratefulifyoucouldinformmeof.../that...Ishouldbeobligedifyouwouldbesokindastoprovidemewithcertainessentialinformationregardingthefollowingaspects.（若能获悉。。。将不胜感激）Iamwritingtoseekforyourassistancein…Iwouldappreciateitifyoucouldprovideuswith…ThequestionsIneedansweringarelistedasfollows. Wouldyoupleasesendmetherelevantinformationandapplicationforms?ShouldIneedtosendfurthermaterials,pleaseletmeknow.Couldyoubesokindastosendmesomerelevantbookletsontheabovementionedaspects?Iameagerlyawaitingyourreplytothismatter.Yourpromptandfavorableattentiontomyinquirywouldbehighlyappreciated.Iwouldliketothankyouforyourgeneroushelpinthismatter.Iamlookingforwardtoafavorablereplyatyourearliestconvenience. 邀请信ALetterofInvitationIamwritingonbehalfofallthestudentsofourdepartmenttoinviteyoutogivealectureon…Iamwritingonbehalfofallthemembersofourclubtoextendtoyouourformalinvitationtovisit…Wewouldbeverygratefulifyoucouldgiveusatalkon…Thehonorofyourpresenceisrequested. I’mconfidentmyprofessionalknowledgehaspreparedmetohandlethejob.（我相信我的专业知识能让我胜任这份工作）Thekindofworkinwhichyourcompanyisengagedparticularlyinterestsme.（贵公司目前从事的这种工作特别让我感兴趣）Itseemstomethatthisexperience,togetherwithmyeducation,hasgivenmeidealpreparationtoassumetheroleof…insuchafirmasyours.（对我来说，这些经验加上我的学历，使我具备了担任贵公司。。。一职的条件）'